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“I think it’s really likely that in the not-too-distant future it will cure genetic disease,” she said. “But globally we need to come up with a consensus on moving forward in a responsible way.” In 2015, Doudna was part of a broad coalition of leading biologists who agreed to a worldwide moratorium on gene editing to the “germ line,” which is to say, edits that get passed along to subsequent generations. But it’s legally non-binding, and scientists in China have already begun experiments that involve editing the genome of human embryos. Using Crispr to cure inheritable genetic diseases is still a long way off, and fraught with ethical potholes. Which is why Doudna said people who are excited about the possibilities of Crispr shouldn’t look to the clinic for its first big successes, but rather to the farm field. “When I think about where we are likely to see the biggest impacts in the shortest amount of time, I really think it’s going to be in agriculture,” she said. Plant breeders have always been geneticists at heart. And with the precision and ease of Crispr, identifying and separating out desirable traits has the potential to speed up new crop development by several orders of magnitude. Agro-giants DuPont and Monsanto have invested in Crispr licenses to accelerate their R&D efforts toward creating crops that can withstand changing climates and new disease and pest burdens. In test plots around the world gene edited crops are already growing—from longer-lasting potatoes and flood-resistant rice to drought-hardy corn and mildew-proof wheat, to name Skip Tracing just a few.
For the original version including any supplementary images or video, visit https://www.wired.com/2017/06/crispr-may-cure-genetic-disease-one-day/